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Clinical Research & Trials

Our clinical research programs evaluate new treatment approaches, technologies, and rehabilitation protocols designed to improve patient outcomes. Through structured clinical studies and data analysis, we continuously refine spine treatment strategies to deliver safer and more effective care.

  • Evidence-based treatment protocols
  • Continuous outcome analysis
  • Collaboration with medical researchers
  • Ethical research practices
Medical team collaborating

A Culture of Continuous Innovation

Our doctors, researchers, and physiotherapists work together to transform decades of clinical experience into new techniques, data-driven protocols, and evidence-based outcomes. With over 100 publications and ongoing clinical studies in minimally invasive, endoscopic, and robotic spine surgery, Stavya is at the forefront of advancing safe and effective spine care.

We collaborate with leading global spine organizations such as ASSI, NASS, and AOSpine to exchange knowledge, contribute to multicenter research, and train the next generation of specialists. Through regular workshops, fellowships, and academic training programs, we ensure that innovation at Stavya extends beyond technology it becomes a way of thinking, learning, and improving patient outcomes every day.

Research and Publications

Research

Research is a part of a growing institution. It involves multitude of steps right from maintaining the data to publication of a paper in national/international journal.

Only few institutes in practice maintain the day-to-day details about the patients visiting to the hospital.

Patients suffering from various spinal ailments are treated conservatively as well as surgically depending upon the symptomatology and findings on different radiological tests.

We at SSHRI record and store all the medical data pertaining to patients visiting to our centre. This medical data is stored in the computers in various sections. This is possible due to dedicated software developed and edited by Stavya consultants.

All the information stored in the computers is analysed by the spinal surgeons and research analysts working in our institute.

Research studies are proposed, planned and executed in a systematic manner. All the proposed research studies are initially planned and discussed among the spine surgeons in the institute. Few studies involve patients clinically, radiological studies which are non-invasive in nature.

Few studies involving newer drugs, newer surgical techniques, newer implants need utmost planning and critical work up before executing. Then in the next stage, Institutional Ethical Committee (IEC) approval is taken for the proposed study. We at SSHRI have an institutional ethical committee since 2009.

Research studies once approved by ethical committee are then executed in proposed ways. Patient consent is taken in all the studies. All the information collected is analysed and then statistically calculated deriving to results.

As a spine surgeon, operating patients is a skilled job, but writing a research paper is a tough job that takes a lot of patience, time and also thinking process.

Submission, Review and finally acceptance – results in a paper publication in reputed national/ international, ortho/ spine journal. We, at SSHRI, have published 16 papers in 2019.

For the benefit of patients, we have uploaded all the published journals of preceding years.

INSTITUTIONAL ETHICS COMMITTEE (SSHRI)

SSHRI has its own institutional ethics committee which supervises all in home funded/nonfunded research project.

Dr. Adarshjitsingh

Chairperson & Medical Scientist

Dr. Mirant Dave

Clinician

Dr. Ajay Krishnan

Clinician

Dr. Shounak Dudhiya

Clinician

Dr. Birju Vyas

Member Secretary

Mr. Mahesh Vaghasia

Legal Expert

Dr. Falguni Majmudar

Scientific Member

Ms. Renuka Patel

Member

Dr. Stuti Shah

Scientific Member

Dr. Birwa Shah

Clinician

Ms. Jimita Raval

Social Scientist

Ms. Jalpa Vyas

Lay Person

Ms. Rekha Trivedi

Legal Expert

1. Completed Studies

a. Investigator initiated studies

  1. The Effect of Sciatic nerve mobilization in patients operated Lumbar (L4 L5 S1) Discectomy.
  2. Clinico-radiological correlation of various fusion techniques for single level lumbar spine disorder
  3. A retrospective study of comparison of clinical outcome of TLIF and laminectomy in patients presenting with cauda equine syndrome with prospective study of clinical outcome of TLIF in patients with cauda equine syndrome.
  4. A Comparison of the efficacy and tolerability of Lornoxicam and Diclofenac Sodium in patients with acute post operative pain after Spinal Surgery
  5. Contrast MRI as a Prognosticator for conservative treatment if Lumbar Disc Prolapse
  6. Clinico radiological correlation with effectiveness of various treatments in patients with coccycodynia and comparison of radiological assessment of coccyx in normal healthy volunteers.
  7. A prospective , cross sectional study to find out correlation between Supine Lying LBP/Leg Pain and Retrolisthesis in Lumbar disc prolapse patient
  8. To Study the effect of neual mamipulation on Haemodynamic parameters during Lumbar spine surgery in Prone position.
  9. A Radiological study of pedicle dimensional variations in Lytic listhesis in Indian population.
  10. The Relationship of Osteoporosis with Hypocalcemia
  11. A prospective analysis of MRI of fibrosis in post - operative TLIF patients conventional vs MISS
  12. Clinico-radiological results of anterior surgery for multilevel cervical spondylotic myelopathy
  13. Importance of immediate Post Operative MRI in Cervical and dorsal myelopathy
  14. Role of contrast MRI in assessment of natural history of lumbar disc prolapse
  15. Evaluation of new onset pain and neurological deficit in post-op lumbar spine surgery
  16. A Retrospective analysis of Clinical and Radiological outcome in Recurrent Disc prolapse
  17. Study of Spinal Sagittal Balance in Indian population along with social and economic perspective
  18. Drain tip culture: would it help us predict and prevent surgical site infection after spinal surgery?
  19. Microbiological spectrum in Post procedural Spondylodiscitis
  20. An academic clinical study to assess the efficacy and safety of Nandrolone decanoate and alendronate as compared to alendronate alone in patients with Osteoporosis
  21. An Observational retrospective & prospective analysis of use, advantages, disadvantages & significance of intraoperative neu-romonitoring in spine surgeries.
  22. An Investigator Initiated study of Redefining the entry point in insertion of cervical pedicle screw using O-arm and Navigation - A prospective radiological study in Indian subjects
  23. "Comparative morphometric analysis of bare window in oblique lumbar interbody fusion indegenerative lumbar scoliosis. "
  24. A prospective multicentric questionnaire-based evaluation of learning curve of first seven consecutive cases of OLIF of a surgeon/institute.
  25. A prospective clinical and radiological study of symptomatic upper lumbar disc herniation in Indian population
  26. Surgical outcomes of upper lumbar disc herniation in Indian population- A prospective analysis.
  27. Retrospective analysis of clinical presentation and surgical outcomes of upper lumbar disc herniation.
  28. Signs of Transforaminal Endoscopic End-Point Decompression: Objective and Subjective evaluation to prevent failures.
  29. TranspedicularVertebral biopsy: Navigated Biopsy technique Improvisation with Integrated Operation Theater Spine Suite (IOTSS)
  30. A retrospective analysis of demographic, clinical and postoperative data of all patients operated at a spine center- Our experience of 18 years
  31. A retrospective analysis of demographic, clinical and postoperative data of all cervical spine patients operated at a spine center - Our experience of 18 years
  32. Retrospective long term follow-up analysis of anterior cervical corpectomy and fusion in cervical myelopathy at tertiary level spine center in India.
  33. Long term clinical and radiological outcomes ofcervical disc arthroplasty at a tertiary level spine center: A retrospective cohort analysis
  34. Occipitocervical fusion using screw rod plate system in craniocervical pathologies: A prospective cohort analysis of long term functional and radiological outcome with minimum 2 years of follow-up.
  35. Kinematic Cervical MRI - An insight into indications and radiological findings - A retrospective radiological analysis
  36. A Retrospective study to find the diagnostic value of stress MRI in management of lumbar spine pathologies with clinical-radiological mismatch
  37. Prospective analysis of immediate post operative MRI in patients with myelopathy
  38. Retrospective analysis of immediate post operative MRI in patients with myelopathy
  39. Comparative study on accuracy of Intraoperative CT-navigation based Screw placement with cutaneous vs bone fixed dynamic reference frame in MIS-TLIF
  40. An analysis of reasons for delay in seeking treatment among patients with neurological deficits
  41. The Twenty – twenty view: a novel technique to assess accuracy of pedicle screw instru- mentation
  42. Procrastinating drain removal”: unconventional but effective management of cerebrospinal fluid leakage following anterior cervical spine surgery: a single center - single surgeon study.
  43. A Exploratory Study and Analysis of Real Word Evidence of Adaptix™ Interbody Cage System at a Tertiary Care Spine Centre.
  44. Prospective comparative analysis of guidewire Vs guide wirelessnavigated percutaneous pedicle screw placement for MISS
  45. An observational, retrospective & prospective study to evaluate the treatment outcomes of atlantoaxial osteoarthritis
  46. A comparative study between vertical and horizontal MISS (Minimally invasive spine surgery) post-operative scar
  47. To Study the prevalence of hand signs in cervical spondylotic myelopthy: A prospective cohort analysis.
  48. The use of chewing gum to enhance recovery of bowel function after Spine surgery: A randomised controlled trial
  49. Detection of Modern Spinal Implants by Handheld Metal Detectors
  50. Multiple-Rod Construct for Occipito-Cervical Fusion: A Retrospective observational study
  51. Spinoxiety: Understanding the Influence of Anxiety on Clinical Perception and Outcomes in Spine Disorders—A Prospective Observational Study
  52. Accuracy Assessment of Planned vs. Actual Trajectories in Robotic Spine Surgery Using Post-Operative CT scans
  53. A Five-Year Comparative Effectiveness Analysis of Anterior Cervical Discectomy and Fusion Versus Cervical Total Disc Replacement.
  54. Determinants Of Adherence to Osteoporosis Treatment in Our Institute.
  55. Surgical Fear and Preference in Spine Disorders: A Prospective Study of Tomophobia and Tomophilia
  56. Evaluation of Clinical Outcomes of Preserving Versus Sacrificing C2 and C7 Spinous Process Attachments in Patients Undergoing Cervical Laminectomy: A retrospective observational study
  57. Assessment of Clinical and Ethical Practices in Spine Consultation Across India: A Patient-Based Observational Study
  58. Institutional analysis: Post‑COVID Health Pursuit by Physical Exercise Leading to an Enhanced Spine Problem in All Cross‑Sectional Age Groups
  59. Evaluation of Clinical Outcomes of Laminectomy versus Laminoplasty in Patients with Intradural Spinal Tumors: A retrospective observational study
  60. EPJF: Endplate Junctional Failure in Lumbar Disc herniation: Transforaminal Endoscopic Management in 113 patients
  61. Transforaminal Lumbar Endoscopic Discectomy/ Decompression at last lumbo-sacral level by transiliac approach.
  62. Transforaminal Lumbar Endoscopic Discectomy in Obese patients.
  63. Fully 3D CT Navigated, TLIF Outcome & Workflow advantage: A study of 44 cases.
  64. A Retrospective analysis of outcomes in multiple revision surgeries in lumbar spine.
  65. A Prospective Observational Cohort Study to Analyze the Etiology of Revision Lumbar Spine Surgeryat a Tertiary Care Spine Institute with 6 months follow-up.
  66. A Prospective Observational Cohort Study to Analyse the Etiology of Revision Lumbar Spine Surgery at a Tertiary Care Spine Institute.
  67. Transforaminal Lumbar Endoscopic Discectomy in Migrated Disc Prolapse (DP): A Study Of 169 Patients
  68. An Investigator Initiated study of O-Arm guided single position OLIF with posterior percutaneous fixation in the same position for Indian patients.
  69. An Investigator Initiated study of Micro structural and DEXA analysis of trabecular architecture in lumbar vertebra - a comparative study in osteoporotic and normal vertebrae among Indian population.

b. Sponsored Studies

  1. A Randomized, Double-Blind, Active-Controlled, Parallel Arm, Multicenter Study Comparing Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Denosumab of Intas Pharmaceutical Limited (60 mg/mL) with Prolia® in Postmenopausal Women with Osteoporosis.
  2. An Open-label, Single-arm, Multicenter Phase 4 Study to Evaluate Safety and Tolerability of Romosozumab (EVENITY®) in Postmenopausal Women in India with Osteoporosis and a High Risk of Fracture (Romosozumab).
  3. A prospective single arm, multi-centric, post marketing clinical follow-up study to evaluate the safety and performance of pedicle screws in patient with spinal disorders
  4. Medication Use Patterns, Treatment Satisfaction and Inadequate Control of Osteoporosis Study(MUSIC-OS):an Asia Pacific study of postmenopausal women treated for osteoporosis in clinical practice
  5. A Multicentric , Randomized, Open –Label, Comparative, Prospective, Clinical trial to Investigate Efficacy and Safety of Diclofenac Sodium I.V. Injection (75mg/2ml)versus Diclofenac Sodium I.M.Injection (75 mg/ 3 ml ) (Voveran (75mg/3ml) for patients with (A) acute post operative pain and (B)Acute Renal Colic

2. Ongoing Studies :

a. Investigator initiated studies

  1. Early Postoperative Recovery and Discharge Patterns Following MIS TLIF in a High-Volume Spine Center.
  2. Clinical Outcomes of MIS TLIF in a High-Volume Spine Center (2022–2025).
  3. Impact of Intraoperative 3D Navigation versus Conventional Fluoroscopy on Clinical, Radiographic and Operational Outcomes in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS TLIF).
  4. Robotic versus Conventional Fluoroscopy-Guided Pedicle Screw Placement in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS TLIF): A Comparative Study of Accuracy, Radiation, and Clinical Outcomes.
  5. Comparative Use of Navigation and Robotics in MIS TLIF: Workflow and Early Outcomes.
  6. Learning Curve of MIS TLIF in a High-Volume Spine Practice.
  7. Cost Analysis of MIS TLIF: Impact of Implant Choice and Technology Use in an Indian Setting
  8. Cervico-dorso-lumbar stenosis (Multiregional spinal stenosis - MRSS) - An Experience of Single Stage Surgery in a Series of 28 Patients with a minimum follow-up of 2 years.
  9. Prospective Comparative Study Evaluating Prophylactic Local Antibiotic Calcium Sulfate Beads [Stimulan] Versus Standard Systemic Antibiotic Prophylaxis in Preventing Surgical Site Infection in Spine Surgeries
  10. Facet Asymmetry and tropism in primary atlantoaxial osteoarthritis: a case-control study.
  11. A prospective evaluation of etiology of supine lying back pain.
  12. To study the Clinical Outcomes of Vacuum IFT, Cryotherapy, TECARor Laser Therapy Combinations on Patients with Spinal Ailments.
  13. Outcome of planned durectomy in thoracic Ossified ligamentum flavum -A Retrospective Observational study
  14. Does Preservation of C2 and C7 Spinous Process Attachments Improve Patient Outcomes in Cervical Laminectomy? A Prospective Observational Study
  15. Does preoperative sarcopenia (based on paraspinal muscle cross-sectional area on MRI) predict achievement of the minimum clinically important difference (MCID) in Oswestry Disability Index (ODI) at 6 months after MIS-TLIF?
  16. Understanding the Psychological Intent and Motivation of National and International Professionals to a Spine Speciality Hospital
  17. Outcome of Percutaneous Navigation-Guided Posterior Iliac Crest Bone Graft Harvesting: In Primary and Revision Minimally Invasive lumbar Interbody fusion
  18. EXPECTORA: A Prospective Observational Study of Expectation-Driven Phenomena in Patients with Spine Disorders
  19. Association of Type 2 Diabetes Mellitus with Vertebral Fractures, Degenerative Spine Disease and Osteoporosis in Adults Aged ≥40 Years: A Prospective Investigator-Initiated Cohort Study
  20. Quantitative MRI assessment of lumbar dural sac area following minimally invasive transforaminal lumbar interbody fusion: a retrospective single-center study
  21. Extubation-to-Mobilisation Interval in Major Spine Surgery: A Prospective Study
  22. Evaluation of Clinical and Radiological Outcomes of Anterior Cervical Hybrid Surgery.
  23. Prospective evaluation of spinal canal remodeling and clinical recovery after MIS-TLIF and open TLIF: Correlation of clinical and functional outcome with improvement in spinal canal diameter
  24. Prospective Evaluation of Indirect Decompression After MIS-TLIF: Correlation of Radiological and Clinical Outcomes
  25. To evaluate the effectiveness of conservative treatment in patients with lumbar disc prolapse
  26. The Role of Oblique Lateral Radiographs and Oblique Sagittal MRI in Diagnosing Cervical Radiculopathy and Myeloradiculopathy: A Correlative Analysis

b. Sponsored studies

  1. A Prospective, Single Arm, Post Market Clinical Follow-up (PMCF) study to Evaluate the Safety and Performance of Cervical System

RESEARCH PUBLICATIONS

Global Spine Journal

The Effectiveness and Safety of Ultrasonic Bone Scalpel Versus Conventional Method in Cervical Laminectomy: A Retrospective Study of 311 Patients Bharat R. Dave, MS, MCh1, Ajay Krishnan, MS1, Ravi Ranjan Rai, MS1, DevanandDegulmadi, MS1, ShivanandMayi, MS1, and MahendraGudhe, MS1 Global Spine Journal 1-7.

Transforaminal Thoracey Interbody Fusion for Thoracey Disc Prolapse: Surgico-radiological Analysis of 18 Cases. Ajay Krishnan, MS, D Devanand, MS, Shivanand Mayi, MS, Mahesh Kulkarni, MS, Chaitanya Reddy MS, Mreetunjay Singh, MS, Ravi Ranjan Rai, MS, Bharat R. Dave, MS. Global spine journal 1-9, 2019. DOI: 10.1177/2192568219870459

Asian Spine Journal

Does the Surgical Timing and Decompression Alone or Fusion Surgery in Lumbar Stenosis Influence Outcome in Cauda Equina Syndrome? Dave BR, Samal P, Sangvi R, Degulmadi D, Patel D, Krishnan A. Asian Spine J. 2019 Apr; 13(2): 198-209. DOI: 10.31616/asj.2018.0168

The Relationship of Facet Joint Orientation and Tropism with Lumbar Disc Herniation and Degenerative Spondylolisthesis in the Lower Lumbar Spine. Degulmadi D, Dave B, Krishnan A, Patel D. Asian Spine J. 2019 Feb; 13(1): 22-28. DOI: 10.31616/asj.2018.0116

Risk factors and surgical treatment for recurrent lumbar disc prolapse – a review of literature. Ajay Krishnan, Mahesh Kulkarni, Mreetaunjay Singh, Chaitanya Reddy, Shivanand Mayi, D. Devanand, Ravi Ranjan Rai, Bharat R. Dave. Asian spine journal 2019; asj.2018.0301., October 15, 2019

European Spine Journal

Age- and sex-related changes in facet orientation and tropism in lower lumbar spine: an MRI study of 600 patients. Degulmadi D, Dave BR, Krishnan A. Eur Spine J. 2019 May; 28(5): 961-966. DOI: 10.1007/s00586-019-05953-y.

Ultrasonic bone scalpel: utility in cervical corpectomy. A technical note. Dave BR, Degulmadi D, Dahibhate S, Krishnan A, Patel D. Eur Spine J. 2019 Feb; 28(2): 380-385. DOI: 10.1007/s00586-018-5536-x

Indian Spine Journal

A novel surgical technique for hydatid cyst involving cervico-thoracic anterior epidural space. Bharat R Dave, Degulmadi Devanand, Ganesh Deshmukh. Indian spine journal. 2019; vol 2(1), 99-101. DOI: 10.4103/isj.isj_17_18

A Rare Case of Giant Cell Tumor of Body of Axis: Surgical Management with Staged Posterior Occipito-cervical Fusion, Anterior Excision, and Reconstruction through Anterior Mandibulotomy. Bharat R. Dave, Gayadhar Behera, Ajay Krishnan, Devanand Degulmadi. Indian spine journal 2019; 2: 179-83. DOI: 10.4103/isj.isj_21_19

An Unconventional and Novel Therapeutic Technique of Anterior Indirect Decompression in a Case of C6–C7 Synovial Cyst Associated with Radiculopathy. Bharat R. Dave, Gayadhar Behera, Yash Shah, Ajay Krishnan. Indian Spine J 2019; 2: 190-4. DOI: 10.4103/isj.isj_9_19

A Clinical and Radiological Study of Non-traumatic Coccygodynia in Indian Population. Bharat R. Dave, Paresh B. Bang, Devanand Degulmadi, Pushpak Samel, Deepak Shah, Ajay Krishnan. Indian Spine J 2019; 2: 128-33. DOI: 10.4103/isj.isj_15_18

Symptomatic Pneumocephalus Following Spine Surgery – an institutional experience and review of literature. Bharat R. Dave, Amit Jain, Devanand Degulmadi, Ajay Kirshnan, Paresh Bang. Indian Spine J 2020. DOI: 10.4103/isj.isj_4_19

A Rare Case of Spontaneous Pseudomeningocele with lytic Spondylolisthesis. Bharat R. Dave, Devanand Degulmadi, Ajay Kirshnan, Paresh Bang. Indian Spine J 2020. DOI: 10.4103/isj.isj_20_19

LATEST PUBLICATIONS

International Orthopaedics

Concomitant Noncontiguous Level (Thoracic & Lumbar) Spinal stenosis in International Orthopaedics-International Ortho.2009,Apr, 33(2):483-8

NCBI

Transpedicular percutaneous biopsy of vertebral body lesions: a series of 71 cases-NCBI- Spinal cord-2009-47,384-389.

International journal of current research

Coexistence of tuberculosis and myeloma causing atlanto-axial instability. Dr. Bharat R Dave, Dr.PuspakSamal, Dr.Devanand. D, Dr Denish patel, Dr. Ankur Patel, Dr. Manish P Barot and Dr. Ajay Krishnan. International journal of current research. Vol. 9, issue, 09, pp.57670-57673, September, 2017

Indian journal of endocrinology

An observational study to assess back pain in patients with severe osteoporosis treated with teriparatide versus antiresorptives: An Indian subpopulation analysis, Harvinder Chhabra,Rajesh Malhotra, Sunil Marwah,Bharat Dave,KyoungahSee,SimratSohal and SirelGurbuz, Indian J Endocrinol Metab. 2015 Jul-Aug; 19(4): 483–490.

Asian spine journal

Two stage surgical management of multilevel symptomatic thoracic haemangioma using ethanol and iliac crest bone graft. Asian spine journal. 2014. Aug; 8(4): 502–505.

European Spine Journal

Andersson lesion: are we misdiagnosing it? A retrospective study of clinico-radiological features and outcome of short segment fixation. Bharat R. Dave, Himanshu Ram, Ajay Krishnan. Eur Spine J (2011) 20:1503–1509. Doi 10.1007/s00586-011-1836-0.

Coexisting lumbar and cervical stenosis (tandem spinal stenosis): an infrequent presentation. Retrospective analysis of single-stage surgery (53 cases), Ajay Krishnan, Bharat R. Dave, Arun Kumar Kambar, and Himanshu Ram. Eur Spine J. 2014 Jan; 23(1): 64–73. Published online 2013 Jun 24. doi: 10.1007/s00586-013-2868-4

CHAPTER IN BOOKS

1. In ASSI texbook chapter written on the transpedicular biopsy techniques.

2. In Paediatric Bone and Joint Infection Chapter written on Spondylo discitis

3. Approach-Related Complications Following Anterior Cervical Spine Surgery: Dysphagia, Dysphonia, and Esophageal Perforations.

✍️ Authors: Bharat R. Dave & D. Devanand
100+

Spine Experts

30,000+

Spine Surgeries

200+

Years of Consolidated Experience

The Stavya Way Talent - Technique - Technology for Spine Care